SC Genotype -What you need to Know

A lot of people are aware of the “normal’ genotype AA, and the sickle cell genotype which is commonly known as SS, but few are aware of the SC genotype. Let’s not even talk about the AC and CC genotypes.

So what is this SC genotype? Is it as serious as SS? How can one distinguish between the two? What are the unique risks associated with it? Why don’t some people show any obvious symptoms?

What is the SC genotype?

In simple words, it is a variant of the sickle cell gene with much the same transmission as the SS genotype. It requires both parents to have at least one “S” in their gene, SC requires both parents to have at least one S and or One C in their gene. So this can come about if any of the following have children:

AC AND AS

SS AND SC

CC AND AS

What are the symptoms?

SC may have same symptoms as SS which include acute and chronic pain, low blood levels, infections and crisis but theirs is much milder. Crises which are episodes of acute illness are less frequent and less intense than SS. However, for a pregnant woman who is SC, childbirth can be really challenging as they are prone to crisis.

How can one distinguish a person with SS from SC Genotype?

Side by side persons with SC and SS genotype may not look different. Other times, the person with SC MAY look more healthy than that with SS. They may share certain features like stature and yellowness of eyes.

So why don’t some people show symptoms?

It is possible for a person with SC genotype not to have any symptoms. However, the risks associated with Sickle Cell disease are still there.

Some Nigerian celebrities with Sickle cell genotype include former big brother winner Laycon and Adekunle Gold.